Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report

Chronic myeloid leukemia (CML) with p190 BCR-ABL is rare. In some cases it is associated with peripheral monocytosis, while bone marrow shows features intermediate between CML and chronic myelomonocytic leukemia. The prognosis is controversial, but in the most recent literature p190 BCR-ABL CML seem...

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Detalles Bibliográficos
Autores principales: Gatti, Arianna, Movilia, Alessandra, Roncoroni, Lucia, Citro, Annalisa, Marinoni, Sara, Brando, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155835/
https://www.ncbi.nlm.nih.gov/pubmed/32300425
http://dx.doi.org/10.14740/jh421w
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author Gatti, Arianna
Movilia, Alessandra
Roncoroni, Lucia
Citro, Annalisa
Marinoni, Sara
Brando, Bruno
author_facet Gatti, Arianna
Movilia, Alessandra
Roncoroni, Lucia
Citro, Annalisa
Marinoni, Sara
Brando, Bruno
author_sort Gatti, Arianna
collection PubMed
description Chronic myeloid leukemia (CML) with p190 BCR-ABL is rare. In some cases it is associated with peripheral monocytosis, while bone marrow shows features intermediate between CML and chronic myelomonocytic leukemia. The prognosis is controversial, but in the most recent literature p190 BCR-ABL CML seems associated with a poor outcome. We report a case of p190 BCR-ABL CML characterized by moderate monocytosis, without deep molecular response (DMR) to an initial imatinib treatment. After imatinib was replaced by dasatinib, a DMR was achieved, however without appreciable effects on monocytosis.
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spelling pubmed-71558352020-04-16 Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report Gatti, Arianna Movilia, Alessandra Roncoroni, Lucia Citro, Annalisa Marinoni, Sara Brando, Bruno J Hematol Case Report Chronic myeloid leukemia (CML) with p190 BCR-ABL is rare. In some cases it is associated with peripheral monocytosis, while bone marrow shows features intermediate between CML and chronic myelomonocytic leukemia. The prognosis is controversial, but in the most recent literature p190 BCR-ABL CML seems associated with a poor outcome. We report a case of p190 BCR-ABL CML characterized by moderate monocytosis, without deep molecular response (DMR) to an initial imatinib treatment. After imatinib was replaced by dasatinib, a DMR was achieved, however without appreciable effects on monocytosis. Elmer Press 2018-09 2018-09-01 /pmc/articles/PMC7155835/ /pubmed/32300425 http://dx.doi.org/10.14740/jh421w Text en Copyright 2018, Gatti et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gatti, Arianna
Movilia, Alessandra
Roncoroni, Lucia
Citro, Annalisa
Marinoni, Sara
Brando, Bruno
Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title_full Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title_fullStr Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title_full_unstemmed Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title_short Chronic Myeloid Leukemia With P190 BCR-ABL Translocation and Persistent Moderate Monocytosis: A Case Report
title_sort chronic myeloid leukemia with p190 bcr-abl translocation and persistent moderate monocytosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155835/
https://www.ncbi.nlm.nih.gov/pubmed/32300425
http://dx.doi.org/10.14740/jh421w
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