A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report

Microangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report a patient who presented with an acute onset of Coombs negative hemolytic anemia and frequent sc...

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Autores principales: Eisa, Noha, Nasef, Khalid, Emarah, Ziad, Fattah, Marwa Mohamed Abdel, Shamaa, Sameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155867/
https://www.ncbi.nlm.nih.gov/pubmed/32300416
http://dx.doi.org/10.14740/jh386e
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author Eisa, Noha
Nasef, Khalid
Emarah, Ziad
Fattah, Marwa Mohamed Abdel
Shamaa, Sameh
author_facet Eisa, Noha
Nasef, Khalid
Emarah, Ziad
Fattah, Marwa Mohamed Abdel
Shamaa, Sameh
author_sort Eisa, Noha
collection PubMed
description Microangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report a patient who presented with an acute onset of Coombs negative hemolytic anemia and frequent schistocytes in the peripheral blood smear which are typical for MAHA as initial presentation of metastatic SRCC. Our patients fulfilled the criteria of thrombotic thrombocytopenic purpura (TTP) and received the specific treatment for TTP without improvement.
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spelling pubmed-71558672020-04-16 A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report Eisa, Noha Nasef, Khalid Emarah, Ziad Fattah, Marwa Mohamed Abdel Shamaa, Sameh J Hematol Case Report Microangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report a patient who presented with an acute onset of Coombs negative hemolytic anemia and frequent schistocytes in the peripheral blood smear which are typical for MAHA as initial presentation of metastatic SRCC. Our patients fulfilled the criteria of thrombotic thrombocytopenic purpura (TTP) and received the specific treatment for TTP without improvement. Elmer Press 2018-05 2018-05-10 /pmc/articles/PMC7155867/ /pubmed/32300416 http://dx.doi.org/10.14740/jh386e Text en Copyright 2018, Eisa et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Eisa, Noha
Nasef, Khalid
Emarah, Ziad
Fattah, Marwa Mohamed Abdel
Shamaa, Sameh
A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title_full A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title_fullStr A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title_full_unstemmed A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title_short A Metastatic Signet Ring Cell Carcinoma Presented as Acquired Thrombotic Thrombocytopenic Purpura: A Case Report
title_sort metastatic signet ring cell carcinoma presented as acquired thrombotic thrombocytopenic purpura: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155867/
https://www.ncbi.nlm.nih.gov/pubmed/32300416
http://dx.doi.org/10.14740/jh386e
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