Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

Guided by computational analysis, herein we report the design, synthesis and evaluation of four novel diazine-based histone deacetylase inhibitors (HDACis). The targets of interest (TOI) are analogues of panobinostat, one of the most potent and versatile HDACi reported. By simply replacing the pheny...

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Detalles Bibliográficos
Autores principales: Balasubramaniam, Sivaraman, Vijayan, Sajith, Goldman, Liam V, May, Xavier A, Dodson, Kyra, Adhikari, Sweta, Rivas, Fatima, Watkins, Davita L, Stoddard, Shana V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155894/
https://www.ncbi.nlm.nih.gov/pubmed/32318119
http://dx.doi.org/10.3762/bjoc.16.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155894/
https://www.ncbi.nlm.nih.gov/pubmed/32318119
http://dx.doi.org/10.3762/bjoc.16.59

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