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In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (Trichosurus vulpecula)

Feline infectious peritonitis (FIP) is a systemic, fatal, viral-induced, immune-mediated disease of cats caused by feline infectious peritonitis virus (FIPV). Mefloquine, a human anti-malarial agent, has been shown to inhibit FIPV in vitro. As a first step to evaluate its efficacy and safety profile...

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Detalles Bibliográficos
Autores principales:	Izes, Aaron Michael, Kimble, Benjamin, Norris, Jacqueline Marie, Govendir, Merran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156057/ https://www.ncbi.nlm.nih.gov/pubmed/32287278 http://dx.doi.org/10.1371/journal.pone.0230975

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