Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice

To explore the contribution of Vav1, a hematopoietic signal transducer, to pancreatic ductal adenocarcinoma (PDAC) development, we generated transgenic mouse lines expressing, Vav1, K-Ras(G12D), or both K-Ras(G12D) and Vav1 in pancreatic acinar cells. Co-expression of Vav1 and K-Ras(G12D) synergisti...

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Detalles Bibliográficos
Autores principales: Salaymeh, Yaser, Farago, Marganit, Sebban, Shulamit, Shalom, Batel, Pikarsky, Eli, Katzav, Shulamit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156281/
https://www.ncbi.nlm.nih.gov/pubmed/32277014
http://dx.doi.org/10.26508/lsa.202000661

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