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The emerging role of RNA modifications in the regulation of mRNA stability

Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding pro...

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Autores principales: Boo, Sung Ho, Kim, Yoon Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156397/
https://www.ncbi.nlm.nih.gov/pubmed/32210357
http://dx.doi.org/10.1038/s12276-020-0407-z
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author Boo, Sung Ho
Kim, Yoon Ki
author_facet Boo, Sung Ho
Kim, Yoon Ki
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description Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding proteins to the mRNAs. Recent advances in high-throughput RNA-sequencing techniques have resulted in the elucidation of the important roles played by mRNA modifications and mRNA nucleotide sequences in regulating mRNA stability. To date, hundreds of different RNA modifications have been characterized. Among them, several RNA modifications, including N(6)-methyladenosine (m(6)A), N(6),2′-O-dimethyladenosine (m(6)Am), 8-oxo-7,8-dihydroguanosine (8-oxoG), pseudouridine (Ψ), 5-methylcytidine (m(5)C), and N(4)-acetylcytidine (ac(4)C), have been shown to regulate mRNA stability, consequently affecting diverse cellular and biological processes. In this review, we discuss our current understanding of the molecular mechanisms underlying the regulation of mammalian mRNA stability by various RNA modifications.
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spelling pubmed-71563972020-04-20 The emerging role of RNA modifications in the regulation of mRNA stability Boo, Sung Ho Kim, Yoon Ki Exp Mol Med Review Article Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding proteins to the mRNAs. Recent advances in high-throughput RNA-sequencing techniques have resulted in the elucidation of the important roles played by mRNA modifications and mRNA nucleotide sequences in regulating mRNA stability. To date, hundreds of different RNA modifications have been characterized. Among them, several RNA modifications, including N(6)-methyladenosine (m(6)A), N(6),2′-O-dimethyladenosine (m(6)Am), 8-oxo-7,8-dihydroguanosine (8-oxoG), pseudouridine (Ψ), 5-methylcytidine (m(5)C), and N(4)-acetylcytidine (ac(4)C), have been shown to regulate mRNA stability, consequently affecting diverse cellular and biological processes. In this review, we discuss our current understanding of the molecular mechanisms underlying the regulation of mammalian mRNA stability by various RNA modifications. Nature Publishing Group UK 2020-03-24 /pmc/articles/PMC7156397/ /pubmed/32210357 http://dx.doi.org/10.1038/s12276-020-0407-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Boo, Sung Ho
Kim, Yoon Ki
The emerging role of RNA modifications in the regulation of mRNA stability
title The emerging role of RNA modifications in the regulation of mRNA stability
title_full The emerging role of RNA modifications in the regulation of mRNA stability
title_fullStr The emerging role of RNA modifications in the regulation of mRNA stability
title_full_unstemmed The emerging role of RNA modifications in the regulation of mRNA stability
title_short The emerging role of RNA modifications in the regulation of mRNA stability
title_sort emerging role of rna modifications in the regulation of mrna stability
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156397/
https://www.ncbi.nlm.nih.gov/pubmed/32210357
http://dx.doi.org/10.1038/s12276-020-0407-z
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