Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

It is unclear why some tissues are refractory to the mitogenic effects of the oncogene Myc. Here we show that Myc activation induces rapid transcriptional responses followed by proliferation in some, but not all, organs. Despite such disparities in proliferative response, Myc is bound to DNA at open...

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Detalles Bibliográficos
Autores principales: Bywater, Megan J., Burkhart, Deborah L., Straube, Jasmin, Sabò, Arianna, Pendino, Vera, Hudson, James E., Quaife-Ryan, Gregory A., Porrello, Enzo R., Rae, James, Parton, Robert G., Kress, Theresia R., Amati, Bruno, Littlewood, Trevor D., Evan, Gerard I., Wilson, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156407/
https://www.ncbi.nlm.nih.gov/pubmed/32286286
http://dx.doi.org/10.1038/s41467-020-15552-x

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