Therapeutics targeting the fibrinolytic system

The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated...

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Autores principales: Lin, Haili, Xu, Luning, Yu, Shujuan, Hong, Wanjin, Huang, Mingdong, Xu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156416/
https://www.ncbi.nlm.nih.gov/pubmed/32152451
http://dx.doi.org/10.1038/s12276-020-0397-x
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author Lin, Haili
Xu, Luning
Yu, Shujuan
Hong, Wanjin
Huang, Mingdong
Xu, Peng
author_facet Lin, Haili
Xu, Luning
Yu, Shujuan
Hong, Wanjin
Huang, Mingdong
Xu, Peng
author_sort Lin, Haili
collection PubMed
description The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
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spelling pubmed-71564162020-04-20 Therapeutics targeting the fibrinolytic system Lin, Haili Xu, Luning Yu, Shujuan Hong, Wanjin Huang, Mingdong Xu, Peng Exp Mol Med Review Article The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed. Nature Publishing Group UK 2020-03-09 /pmc/articles/PMC7156416/ /pubmed/32152451 http://dx.doi.org/10.1038/s12276-020-0397-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Lin, Haili
Xu, Luning
Yu, Shujuan
Hong, Wanjin
Huang, Mingdong
Xu, Peng
Therapeutics targeting the fibrinolytic system
title Therapeutics targeting the fibrinolytic system
title_full Therapeutics targeting the fibrinolytic system
title_fullStr Therapeutics targeting the fibrinolytic system
title_full_unstemmed Therapeutics targeting the fibrinolytic system
title_short Therapeutics targeting the fibrinolytic system
title_sort therapeutics targeting the fibrinolytic system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156416/
https://www.ncbi.nlm.nih.gov/pubmed/32152451
http://dx.doi.org/10.1038/s12276-020-0397-x
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AT hongwanjin therapeuticstargetingthefibrinolyticsystem
AT huangmingdong therapeuticstargetingthefibrinolyticsystem
AT xupeng therapeuticstargetingthefibrinolyticsystem

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