Minimally altering a critical kinase for low-phytate maize

Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands. Phytic acid is considered an anti-nutrient, which sequesters important metal ions, limiting their bioavailability. The lpa mutants of maize contain reduced phytate, thus increase its nut...

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Detalles Bibliográficos
Autores principales: Singh, Alla, Karjagi, Chikkappa, Rakshit, Sujay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156439/
https://www.ncbi.nlm.nih.gov/pubmed/32286385
http://dx.doi.org/10.1038/s41598-020-63016-5
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author Singh, Alla
Karjagi, Chikkappa
Rakshit, Sujay
author_facet Singh, Alla
Karjagi, Chikkappa
Rakshit, Sujay
author_sort Singh, Alla
collection PubMed
description Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands. Phytic acid is considered an anti-nutrient, which sequesters important metal ions, limiting their bioavailability. The lpa mutants of maize contain reduced phytate, thus increase its nutritive value. But low phytate is accompanied by negative pleiotropic effects. This article discusses the importance of lpa2 gene amongst available options, for precise DNA editing to simultaneously improve nutrition and avoid pleiotropic effects.
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spelling pubmed-71564392020-04-19 Minimally altering a critical kinase for low-phytate maize Singh, Alla Karjagi, Chikkappa Rakshit, Sujay Sci Rep Article Nutritional security is of vital importance for combating malnutrition and catering to increasing energy demands. Phytic acid is considered an anti-nutrient, which sequesters important metal ions, limiting their bioavailability. The lpa mutants of maize contain reduced phytate, thus increase its nutritive value. But low phytate is accompanied by negative pleiotropic effects. This article discusses the importance of lpa2 gene amongst available options, for precise DNA editing to simultaneously improve nutrition and avoid pleiotropic effects. Nature Publishing Group UK 2020-04-14 /pmc/articles/PMC7156439/ /pubmed/32286385 http://dx.doi.org/10.1038/s41598-020-63016-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Singh, Alla
Karjagi, Chikkappa
Rakshit, Sujay
Minimally altering a critical kinase for low-phytate maize
title Minimally altering a critical kinase for low-phytate maize
title_full Minimally altering a critical kinase for low-phytate maize
title_fullStr Minimally altering a critical kinase for low-phytate maize
title_full_unstemmed Minimally altering a critical kinase for low-phytate maize
title_short Minimally altering a critical kinase for low-phytate maize
title_sort minimally altering a critical kinase for low-phytate maize
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156439/
https://www.ncbi.nlm.nih.gov/pubmed/32286385
http://dx.doi.org/10.1038/s41598-020-63016-5
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