Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Continuous cancer growth is driven by subsets of self-renewing malignant cells. Targeting of uncontrolled self-renewal through inhibition of stem cell-related signaling pathways has proven challenging. Here, we show that cancer cells can be selectively deprived of self-renewal ability by interfering...

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Detalles Bibliográficos
Autores principales: Morales Torres, Cristina, Wu, Mary Y., Hobor, Sebastijan, Wainwright, Elanor N., Martin, Matthew J., Patel, Harshil, Grey, William, Grönroos, Eva, Howell, Steven, Carvalho, Joana, Snijders, Ambrosius P., Bustin, Michael, Bonnet, Dominique, Smith, Paul D., Swanton, Charles, Howell, Michael, Scaffidi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156485/
https://www.ncbi.nlm.nih.gov/pubmed/32286289
http://dx.doi.org/10.1038/s41467-020-15615-z

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