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Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156495/ https://www.ncbi.nlm.nih.gov/pubmed/32286409 http://dx.doi.org/10.1038/s41598-020-63278-z |
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author | Xu, Wanhong Weese, J. Scott Ojkic, Davor Lung, Oliver Handel, Katherine Berhane, Yohannes |
author_facet | Xu, Wanhong Weese, J. Scott Ojkic, Davor Lung, Oliver Handel, Katherine Berhane, Yohannes |
author_sort | Xu, Wanhong |
collection | PubMed |
description | The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017–2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months. |
format | Online Article Text |
id | pubmed-7156495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71564952020-04-19 Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 Xu, Wanhong Weese, J. Scott Ojkic, Davor Lung, Oliver Handel, Katherine Berhane, Yohannes Sci Rep Article The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017–2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months. Nature Publishing Group UK 2020-04-14 /pmc/articles/PMC7156495/ /pubmed/32286409 http://dx.doi.org/10.1038/s41598-020-63278-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xu, Wanhong Weese, J. Scott Ojkic, Davor Lung, Oliver Handel, Katherine Berhane, Yohannes Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title | Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title_full | Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title_fullStr | Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title_full_unstemmed | Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title_short | Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 |
title_sort | phylogenetic inference of h3n2 canine influenza a outbreak in ontario, canada in 2018 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156495/ https://www.ncbi.nlm.nih.gov/pubmed/32286409 http://dx.doi.org/10.1038/s41598-020-63278-z |
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