Cargando…

Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018

The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological in...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Wanhong, Weese, J. Scott, Ojkic, Davor, Lung, Oliver, Handel, Katherine, Berhane, Yohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156495/
https://www.ncbi.nlm.nih.gov/pubmed/32286409
http://dx.doi.org/10.1038/s41598-020-63278-z
_version_ 1783522219893194752
author Xu, Wanhong
Weese, J. Scott
Ojkic, Davor
Lung, Oliver
Handel, Katherine
Berhane, Yohannes
author_facet Xu, Wanhong
Weese, J. Scott
Ojkic, Davor
Lung, Oliver
Handel, Katherine
Berhane, Yohannes
author_sort Xu, Wanhong
collection PubMed
description The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017–2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months.
format Online
Article
Text
id pubmed-7156495
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71564952020-04-19 Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018 Xu, Wanhong Weese, J. Scott Ojkic, Davor Lung, Oliver Handel, Katherine Berhane, Yohannes Sci Rep Article The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017–2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months. Nature Publishing Group UK 2020-04-14 /pmc/articles/PMC7156495/ /pubmed/32286409 http://dx.doi.org/10.1038/s41598-020-63278-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Xu, Wanhong
Weese, J. Scott
Ojkic, Davor
Lung, Oliver
Handel, Katherine
Berhane, Yohannes
Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title_full Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title_fullStr Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title_full_unstemmed Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title_short Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018
title_sort phylogenetic inference of h3n2 canine influenza a outbreak in ontario, canada in 2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156495/
https://www.ncbi.nlm.nih.gov/pubmed/32286409
http://dx.doi.org/10.1038/s41598-020-63278-z
work_keys_str_mv AT xuwanhong phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018
AT weesejscott phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018
AT ojkicdavor phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018
AT lungoliver phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018
AT handelkatherine phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018
AT berhaneyohannes phylogeneticinferenceofh3n2canineinfluenzaaoutbreakinontariocanadain2018