Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56(+) NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR...

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Detalles Bibliográficos
Autores principales: Pejoski, David, de Rham, Casimir, Martinez-Murillo, Paola, Santoro, Francesco, Auderset, Floriane, Medaglini, Donata, Pozzi, Gianni, Vono, Maria, Lambert, Paul-Henri, Huttner, Angela, Haks, Mariëlle C., Ottenhoff, Tom H. M., Villard, Jean, Siegrist, Claire-Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156503/
https://www.ncbi.nlm.nih.gov/pubmed/32337075
http://dx.doi.org/10.1038/s41541-020-0179-4
Descripción
Sumario:The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56(+) NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)(+) cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR(+) CD56(dim) or cytokine-responsive CD56(bright) NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.

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