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Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration

BACKGROUND: Low pH suppresses the proliferation and cytotoxic activity of CD8+ cytotoxic and natural killer lymphocytes. The hypoxia-regulated transmembrane protein, carbonic anhydrase CA9, converts carbon dioxide produced by the Krebs cycle to bicarbonate and protons that acidify the extracellular...

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Detalles Bibliográficos
Autores principales:	Giatromanolaki, Alexandra, Harris, Adrian L., Banham, Alison H., Contrafouris, Constantinos A., Koukourakis, Michael I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156529/ https://www.ncbi.nlm.nih.gov/pubmed/32066909 http://dx.doi.org/10.1038/s41416-020-0756-3

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