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Leukocyte-Dependent Regulation of Cardiac Fibrosis
Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM dep...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156539/ https://www.ncbi.nlm.nih.gov/pubmed/32322219 http://dx.doi.org/10.3389/fphys.2020.00301 |
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author | Okyere, Ama Dedo Tilley, Douglas G. |
author_facet | Okyere, Ama Dedo Tilley, Douglas G. |
author_sort | Okyere, Ama Dedo |
collection | PubMed |
description | Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM deposition leads to pathological fibrotic remodeling. At this extent, fibrosis gravely disturbs myocardial compliance, and ultimately leads to adverse outcomes like heart failure with heightened mortality. As such, understanding the complexity behind fibrotic remodeling has been a focal point of cardiac research in recent years. Resident cardiac fibroblasts and activated myofibroblasts have been proven integral to the fibrotic response; however, several findings point to additional cell types that may contribute to the development of pathological fibrosis. For one, leukocytes expand in number after injury and exhibit high plasticity, thus their distinct role(s) in cardiac fibrosis is an ongoing and controversial field of study. This review summarizes current findings, focusing on both direct and indirect leukocyte-mediated mechanisms of fibrosis, which may provide novel targeted strategies against fibrotic remodeling. |
format | Online Article Text |
id | pubmed-7156539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71565392020-04-22 Leukocyte-Dependent Regulation of Cardiac Fibrosis Okyere, Ama Dedo Tilley, Douglas G. Front Physiol Physiology Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated cardiac myofibroblasts, which secrete extracellular matrix (ECM) proteins in an effort to replace damaged tissue; however, excessive ECM deposition leads to pathological fibrotic remodeling. At this extent, fibrosis gravely disturbs myocardial compliance, and ultimately leads to adverse outcomes like heart failure with heightened mortality. As such, understanding the complexity behind fibrotic remodeling has been a focal point of cardiac research in recent years. Resident cardiac fibroblasts and activated myofibroblasts have been proven integral to the fibrotic response; however, several findings point to additional cell types that may contribute to the development of pathological fibrosis. For one, leukocytes expand in number after injury and exhibit high plasticity, thus their distinct role(s) in cardiac fibrosis is an ongoing and controversial field of study. This review summarizes current findings, focusing on both direct and indirect leukocyte-mediated mechanisms of fibrosis, which may provide novel targeted strategies against fibrotic remodeling. Frontiers Media S.A. 2020-04-08 /pmc/articles/PMC7156539/ /pubmed/32322219 http://dx.doi.org/10.3389/fphys.2020.00301 Text en Copyright © 2020 Okyere and Tilley. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Okyere, Ama Dedo Tilley, Douglas G. Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title_full | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title_fullStr | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title_full_unstemmed | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title_short | Leukocyte-Dependent Regulation of Cardiac Fibrosis |
title_sort | leukocyte-dependent regulation of cardiac fibrosis |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156539/ https://www.ncbi.nlm.nih.gov/pubmed/32322219 http://dx.doi.org/10.3389/fphys.2020.00301 |
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