Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Mo...

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Detalles Bibliográficos
Autores principales: Citro, Simona, Bellini, Alice, Medda, Alessandro, Sabatini, Maria Elisa, Tagliabue, Marta, Chu, Francesco, Chiocca, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156594/
https://www.ncbi.nlm.nih.gov/pubmed/32322564
http://dx.doi.org/10.3389/fcimb.2020.00143
Descripción
Sumario:P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.

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