Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Mo...

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Autores principales: Citro, Simona, Bellini, Alice, Medda, Alessandro, Sabatini, Maria Elisa, Tagliabue, Marta, Chu, Francesco, Chiocca, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156594/
https://www.ncbi.nlm.nih.gov/pubmed/32322564
http://dx.doi.org/10.3389/fcimb.2020.00143
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author Citro, Simona
Bellini, Alice
Medda, Alessandro
Sabatini, Maria Elisa
Tagliabue, Marta
Chu, Francesco
Chiocca, Susanna
author_facet Citro, Simona
Bellini, Alice
Medda, Alessandro
Sabatini, Maria Elisa
Tagliabue, Marta
Chu, Francesco
Chiocca, Susanna
author_sort Citro, Simona
collection PubMed
description P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.
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spelling pubmed-71565942020-04-22 Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma Citro, Simona Bellini, Alice Medda, Alessandro Sabatini, Maria Elisa Tagliabue, Marta Chu, Francesco Chiocca, Susanna Front Cell Infect Microbiol Cellular and Infection Microbiology P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels. Frontiers Media S.A. 2020-04-08 /pmc/articles/PMC7156594/ /pubmed/32322564 http://dx.doi.org/10.3389/fcimb.2020.00143 Text en Copyright © 2020 Citro, Bellini, Medda, Sabatini, Tagliabue, Chu and Chiocca. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Citro, Simona
Bellini, Alice
Medda, Alessandro
Sabatini, Maria Elisa
Tagliabue, Marta
Chu, Francesco
Chiocca, Susanna
Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title_full Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title_fullStr Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title_short Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma
title_sort human papilloma virus increases δnp63α expression in head and neck squamous cell carcinoma
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156594/
https://www.ncbi.nlm.nih.gov/pubmed/32322564
http://dx.doi.org/10.3389/fcimb.2020.00143
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