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A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions

Begomoviruses (Geminiviridae family) represent a severe constraint to agriculture worldwide. As ssDNA viruses that replicate in the nuclei of infected cells, the nascent viral DNA has to move to the cytoplasm and then to the adjacent cell to cause disease. The begomovirus nuclear shuttle protein (NS...

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Autores principales: Martins, Laura G. C., Raimundo, Gabriel A. S., Ribeiro, Nathalia G. A., Silva, Jose Cleydson F., Euclydes, Nívea C., Loriato, Virgilio A. P., Duarte, Christiane E. M., Fontes, Elizabeth P. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156597/
https://www.ncbi.nlm.nih.gov/pubmed/32322262
http://dx.doi.org/10.3389/fpls.2020.00398
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author Martins, Laura G. C.
Raimundo, Gabriel A. S.
Ribeiro, Nathalia G. A.
Silva, Jose Cleydson F.
Euclydes, Nívea C.
Loriato, Virgilio A. P.
Duarte, Christiane E. M.
Fontes, Elizabeth P. B.
author_facet Martins, Laura G. C.
Raimundo, Gabriel A. S.
Ribeiro, Nathalia G. A.
Silva, Jose Cleydson F.
Euclydes, Nívea C.
Loriato, Virgilio A. P.
Duarte, Christiane E. M.
Fontes, Elizabeth P. B.
author_sort Martins, Laura G. C.
collection PubMed
description Begomoviruses (Geminiviridae family) represent a severe constraint to agriculture worldwide. As ssDNA viruses that replicate in the nuclei of infected cells, the nascent viral DNA has to move to the cytoplasm and then to the adjacent cell to cause disease. The begomovirus nuclear shuttle protein (NSP) assists the intracellular transport of viral DNA from the nucleus to the cytoplasm and cooperates with the movement protein (MP) for the cell-to-cell translocation of viral DNA to uninfected cells. As a facilitator of intra- and intercellular transport of viral DNA, NSP is predicted to associate with host proteins from the nuclear export machinery, the intracytoplasmic active transport system, and the cell-to-cell transport complex. Furthermore, NSP functions as a virulence factor that suppresses antiviral immunity against begomoviruses. In this review, we focus on the protein-protein network that converges on NSP with a high degree of centrality and forms an immune hub against begomoviruses. We also describe the compatible host functions hijacked by NSP to promote the nucleocytoplasmic and intracytoplasmic movement of viral DNA. Finally, we discuss the NSP virulence function as a suppressor of the recently described NSP-interacting kinase 1 (NIK1)-mediated antiviral immunity. Understanding the NSP-host protein-protein interaction (PPI) network will probably pave the way for strategies to generate more durable resistance against begomoviruses.
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spelling pubmed-71565972020-04-22 A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions Martins, Laura G. C. Raimundo, Gabriel A. S. Ribeiro, Nathalia G. A. Silva, Jose Cleydson F. Euclydes, Nívea C. Loriato, Virgilio A. P. Duarte, Christiane E. M. Fontes, Elizabeth P. B. Front Plant Sci Plant Science Begomoviruses (Geminiviridae family) represent a severe constraint to agriculture worldwide. As ssDNA viruses that replicate in the nuclei of infected cells, the nascent viral DNA has to move to the cytoplasm and then to the adjacent cell to cause disease. The begomovirus nuclear shuttle protein (NSP) assists the intracellular transport of viral DNA from the nucleus to the cytoplasm and cooperates with the movement protein (MP) for the cell-to-cell translocation of viral DNA to uninfected cells. As a facilitator of intra- and intercellular transport of viral DNA, NSP is predicted to associate with host proteins from the nuclear export machinery, the intracytoplasmic active transport system, and the cell-to-cell transport complex. Furthermore, NSP functions as a virulence factor that suppresses antiviral immunity against begomoviruses. In this review, we focus on the protein-protein network that converges on NSP with a high degree of centrality and forms an immune hub against begomoviruses. We also describe the compatible host functions hijacked by NSP to promote the nucleocytoplasmic and intracytoplasmic movement of viral DNA. Finally, we discuss the NSP virulence function as a suppressor of the recently described NSP-interacting kinase 1 (NIK1)-mediated antiviral immunity. Understanding the NSP-host protein-protein interaction (PPI) network will probably pave the way for strategies to generate more durable resistance against begomoviruses. Frontiers Media S.A. 2020-04-08 /pmc/articles/PMC7156597/ /pubmed/32322262 http://dx.doi.org/10.3389/fpls.2020.00398 Text en Copyright © 2020 Martins, Raimundo, Ribeiro, Silva, Euclydes, Loriato, Duarte and Fontes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Martins, Laura G. C.
Raimundo, Gabriel A. S.
Ribeiro, Nathalia G. A.
Silva, Jose Cleydson F.
Euclydes, Nívea C.
Loriato, Virgilio A. P.
Duarte, Christiane E. M.
Fontes, Elizabeth P. B.
A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title_full A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title_fullStr A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title_full_unstemmed A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title_short A Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions
title_sort begomovirus nuclear shuttle protein-interacting immune hub: hijacking host transport activities and suppressing incompatible functions
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156597/
https://www.ncbi.nlm.nih.gov/pubmed/32322262
http://dx.doi.org/10.3389/fpls.2020.00398
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