Cargando…
ATF6 as a Nodal Regulator of Proteostasis in the Heart
Proteostasis encompasses a homeostatic cellular network in all cells that maintains the integrity of the proteome, which is critical for optimal cellular function. The components of the proteostasis network include protein synthesis, folding, trafficking, and degradation. Cardiac myocytes have a spe...
Autores principales: | Glembotski, Christopher C., Arrieta, Adrian, Blackwood, Erik A., Stauffer, Winston T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156617/ https://www.ncbi.nlm.nih.gov/pubmed/32322217 http://dx.doi.org/10.3389/fphys.2020.00267 |
Ejemplares similares
-
Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis
por: Blackwood, Erik A., et al.
Publicado: (2020) -
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart
por: Arrieta, Adrian, et al.
Publicado: (2020) -
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α
por: Stauffer, Winston T., et al.
Publicado: (2020) -
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
por: Stauffer, Winston T., et al.
Publicado: (2020) -
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
por: Blackwood, Erik A., et al.
Publicado: (2019)