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Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries

Non-cariogenic sweet substances, like sugar alcohols, are used to decrease the risk of caries by reducing the growth of dental plaque. The aim of our study was to reveal the impact of xylitol and erythritol on the growth and biofilm formation of cariogenic bacteria including as a novelty, set of cli...

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Autores principales: Kõljalg, Siiri, Smidt, Imbi, Chakrabarti, Anirikh, Bosscher, Douwina, Mändar, Reet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156733/
https://www.ncbi.nlm.nih.gov/pubmed/32286378
http://dx.doi.org/10.1038/s41598-020-63153-x
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author Kõljalg, Siiri
Smidt, Imbi
Chakrabarti, Anirikh
Bosscher, Douwina
Mändar, Reet
author_facet Kõljalg, Siiri
Smidt, Imbi
Chakrabarti, Anirikh
Bosscher, Douwina
Mändar, Reet
author_sort Kõljalg, Siiri
collection PubMed
description Non-cariogenic sweet substances, like sugar alcohols, are used to decrease the risk of caries by reducing the growth of dental plaque. The aim of our study was to reveal the impact of xylitol and erythritol on the growth and biofilm formation of cariogenic bacteria including as a novelty, set of clinical mutans streptococci and Scardovia wiggsiae and to assess the possible synergistic influence of these polyols. We found both xylitol and erythritol to express high growth inhibition effect on cariogenic bacteria. In synergistic effect experiments, 10% polyol combination with excess of erythritol was found to be more effective against growth of Streptococcus mutans and the combination with excess of xylitol more effective against growth of Streptococcus sobrinus and S. wiggsiae. In biofilm inhibition experiments, solutions of 10% polyols in different combinations and 15% single polyols were equally effective against mutans streptococci. At the same time, higher biofilm formation of S. wiggsiae compared to experiments without polyols was detected in different polyol concentrations for up to 34%. In conclusion, both erythritol and xylitol as well as their combinations inhibit the growth of different cariogenic bacteria. Biofilm formation of mutans streptococci is also strongly inhibited. When applying polyols in caries prophylaxis, it is relevant to consider that the profile of pathogens in a particular patient may influence the effect of polyols used.
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spelling pubmed-71567332020-04-22 Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries Kõljalg, Siiri Smidt, Imbi Chakrabarti, Anirikh Bosscher, Douwina Mändar, Reet Sci Rep Article Non-cariogenic sweet substances, like sugar alcohols, are used to decrease the risk of caries by reducing the growth of dental plaque. The aim of our study was to reveal the impact of xylitol and erythritol on the growth and biofilm formation of cariogenic bacteria including as a novelty, set of clinical mutans streptococci and Scardovia wiggsiae and to assess the possible synergistic influence of these polyols. We found both xylitol and erythritol to express high growth inhibition effect on cariogenic bacteria. In synergistic effect experiments, 10% polyol combination with excess of erythritol was found to be more effective against growth of Streptococcus mutans and the combination with excess of xylitol more effective against growth of Streptococcus sobrinus and S. wiggsiae. In biofilm inhibition experiments, solutions of 10% polyols in different combinations and 15% single polyols were equally effective against mutans streptococci. At the same time, higher biofilm formation of S. wiggsiae compared to experiments without polyols was detected in different polyol concentrations for up to 34%. In conclusion, both erythritol and xylitol as well as their combinations inhibit the growth of different cariogenic bacteria. Biofilm formation of mutans streptococci is also strongly inhibited. When applying polyols in caries prophylaxis, it is relevant to consider that the profile of pathogens in a particular patient may influence the effect of polyols used. Nature Publishing Group UK 2020-04-14 /pmc/articles/PMC7156733/ /pubmed/32286378 http://dx.doi.org/10.1038/s41598-020-63153-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kõljalg, Siiri
Smidt, Imbi
Chakrabarti, Anirikh
Bosscher, Douwina
Mändar, Reet
Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title_full Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title_fullStr Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title_full_unstemmed Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title_short Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
title_sort exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156733/
https://www.ncbi.nlm.nih.gov/pubmed/32286378
http://dx.doi.org/10.1038/s41598-020-63153-x
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