Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Female children and adults typically generate more efficacious immune responses to vaccines and infections than age-matched males, but also suffer greater immunopathology and autoimmune disease. We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South Africa,...

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Detalles Bibliográficos
Autores principales: Adland, Emily, Millar, Jane, Bengu, Nomonde, Muenchhoff, Maximilian, Fillis, Rowena, Sprenger, Kenneth, Ntlantsana, Vuyokasi, Roider, Julia, Vieira, Vinicius, Govender, Katya, Adamson, John, Nxele, Nelisiwe, Ochsenbauer, Christina, Kappes, John, Mori, Luisa, van Lobenstein, Jeroen, Graza, Yeney, Chinniah, Kogielambal, Kapongo, Constant, Bhoola, Roopesh, Krishna, Malini, Matthews, Philippa C., Poderos, Ruth Penya, Lluch, Marta Colomer, Puertas, Maria C., Prado, Julia G., McKerrow, Neil, Archary, Moherndran, Ndung’u, Thumbi, Groll, Andreas, Jooste, Pieter, Martinez-Picado, Javier, Altfeld, Marcus, Goulder, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156749/
https://www.ncbi.nlm.nih.gov/pubmed/32286302
http://dx.doi.org/10.1038/s41467-020-15632-y

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