Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

We have investigated Amblyomin-X-treated horse melanomas to better understand its mode of action through transcriptome analysis and the in vivo model. Amblyomin-X is a Kunitz-type homologous protein that selectively leads to the death of tumor cells via ER stress and apoptosis, currently under inves...

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Detalles Bibliográficos
Autores principales: Lichtenstein, Flavio, Iqbal, Asif, de Lima Will, Sonia Elisabete Alves, Bosch, Rosemary Viola, DeOcesano-Pereira, Carlos, Goldfeder, Mauricio Barbugiani, Chammas, Roger, Trufen, Carlos Eduardo Madureira, Morais, Katia Luciano Pereira, de Souza, Jean Gabriel, Natalino, Renato Jose Mendonça, de Azevedo, Inacio Junqueira, Nishiyama Junior, Milton Yutaka, Oliveira, Ursula, Alves, Francisco Ivanio Arruda, Araujo, Jaqueline Mayara, Lobba, Aline Ramos Maia, Chudzinski-Tavassi, Ana Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156751/
https://www.ncbi.nlm.nih.gov/pubmed/32286411
http://dx.doi.org/10.1038/s41598-020-63275-2

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