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Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model
Intrahepatic cholangiocarcinoma (ICC) remains a highly heterogeneous disease with poor prognosis. Tumor‐infiltrating lymphocytes were predictive in various cancers, but their prognostic value in ICC is less clear. A total of 168 ICC patients who had received liver resection were enrolled and assigne...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156843/ https://www.ncbi.nlm.nih.gov/pubmed/31971309 http://dx.doi.org/10.1111/cas.14315 |
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author | Tian, Mengxin Liu, Weiren Tao, Chenyang Tang, Zheng Zhou, Yufu Song, Shushu Jin, Lei Wang, Han Jiang, Xifei Zhou, Peiyun Fang, Yuan Qu, Weifeng Ding, Zhenbin Peng, Yuanfei Fu, Xiutao Qiu, Shuangjian Zhou, Jian Fan, Jia Shi, Yinghong |
author_facet | Tian, Mengxin Liu, Weiren Tao, Chenyang Tang, Zheng Zhou, Yufu Song, Shushu Jin, Lei Wang, Han Jiang, Xifei Zhou, Peiyun Fang, Yuan Qu, Weifeng Ding, Zhenbin Peng, Yuanfei Fu, Xiutao Qiu, Shuangjian Zhou, Jian Fan, Jia Shi, Yinghong |
author_sort | Tian, Mengxin |
collection | PubMed |
description | Intrahepatic cholangiocarcinoma (ICC) remains a highly heterogeneous disease with poor prognosis. Tumor‐infiltrating lymphocytes were predictive in various cancers, but their prognostic value in ICC is less clear. A total of 168 ICC patients who had received liver resection were enrolled and assigned to the derivation cohort. Sixteen immune markers in tumor and peritumor regions were examined by immunohistochemistry. A least absolute shrinkage and selection operator model was used to identify prognostic markers and to establish an immune signature for ICC (IS(ICC)). An IS(ICC)‐applied prediction model was built and validated in another independent dataset. Five immune features, including CD3(peritumor (P)), CD57(P), CD45RA(P), CD66b(intratumoral (T)) and PD‐L1(P), were identified and integrated into an individualized IS(ICC) for each patient. Seven prognostic predictors, including total bilirubin, tumor numbers, CEA, CA19‐9, GGT, HBsAg and IS(ICC), were integrated into the final model. The C‐index of the IS(ICC)‐applied prediction model was 0.719 (95% CI, 0.660‐0.777) in the derivation cohort and 0.667 (95% CI, 0.581‐0.732) in the validation cohort. Compared with the conventional staging systems, the new model presented better homogeneity and a lower Akaike information criteria value in ICC. The IS(ICC)‐applied prediction model may provide a better prediction performance for the overall survival of patients with resectable ICC in clinical practice. |
format | Online Article Text |
id | pubmed-7156843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71568432020-04-20 Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model Tian, Mengxin Liu, Weiren Tao, Chenyang Tang, Zheng Zhou, Yufu Song, Shushu Jin, Lei Wang, Han Jiang, Xifei Zhou, Peiyun Fang, Yuan Qu, Weifeng Ding, Zhenbin Peng, Yuanfei Fu, Xiutao Qiu, Shuangjian Zhou, Jian Fan, Jia Shi, Yinghong Cancer Sci Original Articles Intrahepatic cholangiocarcinoma (ICC) remains a highly heterogeneous disease with poor prognosis. Tumor‐infiltrating lymphocytes were predictive in various cancers, but their prognostic value in ICC is less clear. A total of 168 ICC patients who had received liver resection were enrolled and assigned to the derivation cohort. Sixteen immune markers in tumor and peritumor regions were examined by immunohistochemistry. A least absolute shrinkage and selection operator model was used to identify prognostic markers and to establish an immune signature for ICC (IS(ICC)). An IS(ICC)‐applied prediction model was built and validated in another independent dataset. Five immune features, including CD3(peritumor (P)), CD57(P), CD45RA(P), CD66b(intratumoral (T)) and PD‐L1(P), were identified and integrated into an individualized IS(ICC) for each patient. Seven prognostic predictors, including total bilirubin, tumor numbers, CEA, CA19‐9, GGT, HBsAg and IS(ICC), were integrated into the final model. The C‐index of the IS(ICC)‐applied prediction model was 0.719 (95% CI, 0.660‐0.777) in the derivation cohort and 0.667 (95% CI, 0.581‐0.732) in the validation cohort. Compared with the conventional staging systems, the new model presented better homogeneity and a lower Akaike information criteria value in ICC. The IS(ICC)‐applied prediction model may provide a better prediction performance for the overall survival of patients with resectable ICC in clinical practice. John Wiley and Sons Inc. 2020-02-12 2020-04 /pmc/articles/PMC7156843/ /pubmed/31971309 http://dx.doi.org/10.1111/cas.14315 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Tian, Mengxin Liu, Weiren Tao, Chenyang Tang, Zheng Zhou, Yufu Song, Shushu Jin, Lei Wang, Han Jiang, Xifei Zhou, Peiyun Fang, Yuan Qu, Weifeng Ding, Zhenbin Peng, Yuanfei Fu, Xiutao Qiu, Shuangjian Zhou, Jian Fan, Jia Shi, Yinghong Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title | Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title_full | Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title_fullStr | Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title_full_unstemmed | Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title_short | Prediction of overall survival in resectable intrahepatic cholangiocarcinoma: IS(ICC)‐applied prediction model |
title_sort | prediction of overall survival in resectable intrahepatic cholangiocarcinoma: is(icc)‐applied prediction model |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156843/ https://www.ncbi.nlm.nih.gov/pubmed/31971309 http://dx.doi.org/10.1111/cas.14315 |
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