Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance of tolerance. However, whether microbiota-derived metabolites can modulate Breg suppressive function remains unknown. Here, we demonstrate that rheumatoid arthriti...

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Detalles Bibliográficos
Autores principales: Rosser, Elizabeth C., Piper, Christopher J.M., Matei, Diana E., Blair, Paul A., Rendeiro, André F., Orford, Michael, Alber, Dagmar G., Krausgruber, Thomas, Catalan, Diego, Klein, Nigel, Manson, Jessica J., Drozdov, Ignat, Bock, Christoph, Wedderburn, Lucy R., Eaton, Simon, Mauri, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156916/
https://www.ncbi.nlm.nih.gov/pubmed/32213346
http://dx.doi.org/10.1016/j.cmet.2020.03.003

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