Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach

The work began with the screening of a library of 700,000 small molecules for inhibitors of Trypanosoma brucei growth (a phenotypic screen). The resulting set of 1035 hit compounds was reviewed by a team of medicinal chemists, leading to the nomination of 17 chemically distinct scaffolds for further...

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Detalles Bibliográficos
Autores principales: Buckner, Frederick S., Buchynskyy, Andriy, Nagendar, Pendem, Patrick, Donald A., Gillespie, J. Robert, Herbst, Zackary, Tidwell, Richard R., Gelb, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157241/
https://www.ncbi.nlm.nih.gov/pubmed/32033395
http://dx.doi.org/10.3390/tropicalmed5010023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157241/
https://www.ncbi.nlm.nih.gov/pubmed/32033395
http://dx.doi.org/10.3390/tropicalmed5010023

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