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Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach
The work began with the screening of a library of 700,000 small molecules for inhibitors of Trypanosoma brucei growth (a phenotypic screen). The resulting set of 1035 hit compounds was reviewed by a team of medicinal chemists, leading to the nomination of 17 chemically distinct scaffolds for further...
Autores principales: | Buckner, Frederick S., Buchynskyy, Andriy, Nagendar, Pendem, Patrick, Donald A., Gillespie, J. Robert, Herbst, Zackary, Tidwell, Richard R., Gelb, Michael H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157241/ https://www.ncbi.nlm.nih.gov/pubmed/32033395 http://dx.doi.org/10.3390/tropicalmed5010023 |
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