Cargando…

Membrane Fusion

Entry of enveloped viruses is mediated by viral glycoproteins that catalyze fusion of viral and cellular membranes. These viral glycoproteins need to be activated which leads to extensive conformational changes that trigger the insertion or attachment of a fusion peptide in or to cellular target mem...

Descripción completa

Detalles Bibliográficos
Autores principales: Hock, M., Weissenhorn, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157460/
http://dx.doi.org/10.1016/B978-0-12-801238-3.04814-5
_version_ 1783522347187175424
author Hock, M.
Weissenhorn, W.
author_facet Hock, M.
Weissenhorn, W.
author_sort Hock, M.
collection PubMed
description Entry of enveloped viruses is mediated by viral glycoproteins that catalyze fusion of viral and cellular membranes. These viral glycoproteins need to be activated which leads to extensive conformational changes that trigger the insertion or attachment of a fusion peptide in or to cellular target membranes thus bridging two bilayers. Further refolding into a hairpin-like structure pulls viral and cellular membranes into close apposition, a process that leads to lipid bilayer fusion. Although viral fusion proteins belong to three different classes based on their structural organization, they follow similar structural principles to achieve fusion.
format Online
Article
Text
id pubmed-7157460
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-71574602020-04-15 Membrane Fusion Hock, M. Weissenhorn, W. Reference Module in Biomedical Sciences Article Entry of enveloped viruses is mediated by viral glycoproteins that catalyze fusion of viral and cellular membranes. These viral glycoproteins need to be activated which leads to extensive conformational changes that trigger the insertion or attachment of a fusion peptide in or to cellular target membranes thus bridging two bilayers. Further refolding into a hairpin-like structure pulls viral and cellular membranes into close apposition, a process that leads to lipid bilayer fusion. Although viral fusion proteins belong to three different classes based on their structural organization, they follow similar structural principles to achieve fusion. 2014 2014-11-28 /pmc/articles/PMC7157460/ http://dx.doi.org/10.1016/B978-0-12-801238-3.04814-5 Text en Copyright © 2014 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hock, M.
Weissenhorn, W.
Membrane Fusion
title Membrane Fusion
title_full Membrane Fusion
title_fullStr Membrane Fusion
title_full_unstemmed Membrane Fusion
title_short Membrane Fusion
title_sort membrane fusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157460/
http://dx.doi.org/10.1016/B978-0-12-801238-3.04814-5
work_keys_str_mv AT hockm membranefusion
AT weissenhornw membranefusion