Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca(V)3.1 as the Cell Surface Receptor

Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca(2+) channel Ca(V)3.1 as the DNT receptor by CRISPR-Cas9-based genome-wide scree...

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Detalles Bibliográficos
Autores principales: Teruya, Shihono, Hiramatsu, Yukihiro, Nakamura, Keiji, Fukui-Miyazaki, Aya, Tsukamoto, Kentaro, Shinoda, Noriko, Motooka, Daisuke, Nakamura, Shota, Ishigaki, Keisuke, Shinzawa, Naoaki, Nishida, Takashi, Sugihara, Fuminori, Maeda, Yusuke, Horiguchi, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157530/
https://www.ncbi.nlm.nih.gov/pubmed/32209694
http://dx.doi.org/10.1128/mBio.03146-19

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