Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection

Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 and TcG4 in a nanovector and evaluated whether nano-immunotherapy (referred a...

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Detalles Bibliográficos
Autores principales: Lokugamage, Nandadeva, Choudhuri, Subhadip, Davies, Carolina, Chowdhury, Imran Hussain, Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157635/
https://www.ncbi.nlm.nih.gov/pubmed/32098116
http://dx.doi.org/10.3390/vaccines8010096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157635/
https://www.ncbi.nlm.nih.gov/pubmed/32098116
http://dx.doi.org/10.3390/vaccines8010096

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