The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History

With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that...

Descripción completa

Detalles Bibliográficos
Autor principal: P. De Koning, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157662/
https://www.ncbi.nlm.nih.gov/pubmed/31963784
http://dx.doi.org/10.3390/tropicalmed5010014
_version_ 1783522393542623232
author P. De Koning, Harry
author_facet P. De Koning, Harry
author_sort P. De Koning, Harry
collection PubMed
description With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.
format Online
Article
Text
id pubmed-7157662
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71576622020-05-01 The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History P. De Koning, Harry Trop Med Infect Dis Review With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today. MDPI 2020-01-19 /pmc/articles/PMC7157662/ /pubmed/31963784 http://dx.doi.org/10.3390/tropicalmed5010014 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
P. De Koning, Harry
The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title_full The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title_fullStr The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title_full_unstemmed The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title_short The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
title_sort drugs of sleeping sickness: their mechanisms of action and resistance, and a brief history
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157662/
https://www.ncbi.nlm.nih.gov/pubmed/31963784
http://dx.doi.org/10.3390/tropicalmed5010014
work_keys_str_mv AT pdekoningharry thedrugsofsleepingsicknesstheirmechanismsofactionandresistanceandabriefhistory
AT pdekoningharry drugsofsleepingsicknesstheirmechanismsofactionandresistanceandabriefhistory

Ejemplares similares