Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes

The safety and genetic stability of V4020, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC-83 strain, was evaluated in mice. V4020 was generated from infectious DNA, contains a stabilizing mutation in the E2-120 glycoprotein, and includes rearrangemen...

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Detalles Bibliográficos
Autores principales: Johnson, Dylan M., Sokoloski, Kevin J., Jokinen, Jenny D., Pfeffer, Tia L., Chu, Yong-Kyu, Adcock, Robert S., Chung, Donghoon, Tretyakova, Irina, Pushko, Peter, Lukashevich, Igor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157698/
https://www.ncbi.nlm.nih.gov/pubmed/32121666
http://dx.doi.org/10.3390/vaccines8010114

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