Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside

Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies t...

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Detalles Bibliográficos
Autores principales: Siracusano, Gabriel, Tagliamonte, Maria, Buonaguro, Luigi, Lopalco, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157713/
https://www.ncbi.nlm.nih.gov/pubmed/31991677
http://dx.doi.org/10.3390/vaccines8010041
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author Siracusano, Gabriel
Tagliamonte, Maria
Buonaguro, Luigi
Lopalco, Lucia
author_facet Siracusano, Gabriel
Tagliamonte, Maria
Buonaguro, Luigi
Lopalco, Lucia
author_sort Siracusano, Gabriel
collection PubMed
description Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.
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spelling pubmed-71577132020-04-21 Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside Siracusano, Gabriel Tagliamonte, Maria Buonaguro, Luigi Lopalco, Lucia Vaccines (Basel) Review Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics. MDPI 2020-01-24 /pmc/articles/PMC7157713/ /pubmed/31991677 http://dx.doi.org/10.3390/vaccines8010041 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siracusano, Gabriel
Tagliamonte, Maria
Buonaguro, Luigi
Lopalco, Lucia
Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title_full Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title_fullStr Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title_full_unstemmed Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title_short Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside
title_sort cell surface proteins in hepatocellular carcinoma: from bench to bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157713/
https://www.ncbi.nlm.nih.gov/pubmed/31991677
http://dx.doi.org/10.3390/vaccines8010041
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