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Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar

Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household cont...

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Autores principales: Kyaw, Nang Thu Thu, Sithu, Aung, Satyanarayana, Srinath, Kumar, Ajay M. V., Thein, Saw, Thi, Aye Myat, Wai, Pyae Phyo, Lin, Yan Naing, Kyaw, Khine Wut Yee, Tun, Moe Myint Theingi, Oo, Myo Minn, Aung, Si Thu, Harries, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157714/
https://www.ncbi.nlm.nih.gov/pubmed/31881646
http://dx.doi.org/10.3390/tropicalmed5010002
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author Kyaw, Nang Thu Thu
Sithu, Aung
Satyanarayana, Srinath
Kumar, Ajay M. V.
Thein, Saw
Thi, Aye Myat
Wai, Pyae Phyo
Lin, Yan Naing
Kyaw, Khine Wut Yee
Tun, Moe Myint Theingi
Oo, Myo Minn
Aung, Si Thu
Harries, Anthony D.
author_facet Kyaw, Nang Thu Thu
Sithu, Aung
Satyanarayana, Srinath
Kumar, Ajay M. V.
Thein, Saw
Thi, Aye Myat
Wai, Pyae Phyo
Lin, Yan Naing
Kyaw, Khine Wut Yee
Tun, Moe Myint Theingi
Oo, Myo Minn
Aung, Si Thu
Harries, Anthony D.
author_sort Kyaw, Nang Thu Thu
collection PubMed
description Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%–6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%–24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar.
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spelling pubmed-71577142020-04-21 Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar Kyaw, Nang Thu Thu Sithu, Aung Satyanarayana, Srinath Kumar, Ajay M. V. Thein, Saw Thi, Aye Myat Wai, Pyae Phyo Lin, Yan Naing Kyaw, Khine Wut Yee Tun, Moe Myint Theingi Oo, Myo Minn Aung, Si Thu Harries, Anthony D. Trop Med Infect Dis Article Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%–6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%–24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar. MDPI 2019-12-25 /pmc/articles/PMC7157714/ /pubmed/31881646 http://dx.doi.org/10.3390/tropicalmed5010002 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kyaw, Nang Thu Thu
Sithu, Aung
Satyanarayana, Srinath
Kumar, Ajay M. V.
Thein, Saw
Thi, Aye Myat
Wai, Pyae Phyo
Lin, Yan Naing
Kyaw, Khine Wut Yee
Tun, Moe Myint Theingi
Oo, Myo Minn
Aung, Si Thu
Harries, Anthony D.
Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title_full Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title_fullStr Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title_full_unstemmed Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title_short Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
title_sort outcomes of community-based systematic screening of household contacts of patients with multidrug-resistant tuberculosis in myanmar
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157714/
https://www.ncbi.nlm.nih.gov/pubmed/31881646
http://dx.doi.org/10.3390/tropicalmed5010002
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