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Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar
Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household cont...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157714/ https://www.ncbi.nlm.nih.gov/pubmed/31881646 http://dx.doi.org/10.3390/tropicalmed5010002 |
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author | Kyaw, Nang Thu Thu Sithu, Aung Satyanarayana, Srinath Kumar, Ajay M. V. Thein, Saw Thi, Aye Myat Wai, Pyae Phyo Lin, Yan Naing Kyaw, Khine Wut Yee Tun, Moe Myint Theingi Oo, Myo Minn Aung, Si Thu Harries, Anthony D. |
author_facet | Kyaw, Nang Thu Thu Sithu, Aung Satyanarayana, Srinath Kumar, Ajay M. V. Thein, Saw Thi, Aye Myat Wai, Pyae Phyo Lin, Yan Naing Kyaw, Khine Wut Yee Tun, Moe Myint Theingi Oo, Myo Minn Aung, Si Thu Harries, Anthony D. |
author_sort | Kyaw, Nang Thu Thu |
collection | PubMed |
description | Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%–6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%–24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar. |
format | Online Article Text |
id | pubmed-7157714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71577142020-04-21 Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar Kyaw, Nang Thu Thu Sithu, Aung Satyanarayana, Srinath Kumar, Ajay M. V. Thein, Saw Thi, Aye Myat Wai, Pyae Phyo Lin, Yan Naing Kyaw, Khine Wut Yee Tun, Moe Myint Theingi Oo, Myo Minn Aung, Si Thu Harries, Anthony D. Trop Med Infect Dis Article Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%–6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%–24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar. MDPI 2019-12-25 /pmc/articles/PMC7157714/ /pubmed/31881646 http://dx.doi.org/10.3390/tropicalmed5010002 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kyaw, Nang Thu Thu Sithu, Aung Satyanarayana, Srinath Kumar, Ajay M. V. Thein, Saw Thi, Aye Myat Wai, Pyae Phyo Lin, Yan Naing Kyaw, Khine Wut Yee Tun, Moe Myint Theingi Oo, Myo Minn Aung, Si Thu Harries, Anthony D. Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title | Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title_full | Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title_fullStr | Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title_full_unstemmed | Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title_short | Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar |
title_sort | outcomes of community-based systematic screening of household contacts of patients with multidrug-resistant tuberculosis in myanmar |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157714/ https://www.ncbi.nlm.nih.gov/pubmed/31881646 http://dx.doi.org/10.3390/tropicalmed5010002 |
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