Cargando…
Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, w...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157722/ https://www.ncbi.nlm.nih.gov/pubmed/32204480 http://dx.doi.org/10.3390/pathogens9030228 |
_version_ | 1783522407587250176 |
---|---|
author | Van Dijck, Christophe Laumen, Jolein G. E. Manoharan-Basil, Sheeba S. Kenyon, Chris |
author_facet | Van Dijck, Christophe Laumen, Jolein G. E. Manoharan-Basil, Sheeba S. Kenyon, Chris |
author_sort | Van Dijck, Christophe |
collection | PubMed |
description | Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal Neisseria are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral Neisseria communities of intimate partners were more similar than those of unrelated individuals (average Morisita–Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (p = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (p = 0.006)). This similarity presumably results from transmission of oral Neisseria through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in Neisseria. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence. |
format | Online Article Text |
id | pubmed-7157722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71577222020-04-21 Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance Van Dijck, Christophe Laumen, Jolein G. E. Manoharan-Basil, Sheeba S. Kenyon, Chris Pathogens Brief Report Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal Neisseria are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral Neisseria communities of intimate partners were more similar than those of unrelated individuals (average Morisita–Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (p = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (p = 0.006)). This similarity presumably results from transmission of oral Neisseria through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in Neisseria. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence. MDPI 2020-03-19 /pmc/articles/PMC7157722/ /pubmed/32204480 http://dx.doi.org/10.3390/pathogens9030228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Van Dijck, Christophe Laumen, Jolein G. E. Manoharan-Basil, Sheeba S. Kenyon, Chris Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title | Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title_full | Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title_fullStr | Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title_full_unstemmed | Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title_short | Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
title_sort | commensal neisseria are shared between sexual partners: implications for gonococcal and meningococcal antimicrobial resistance |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157722/ https://www.ncbi.nlm.nih.gov/pubmed/32204480 http://dx.doi.org/10.3390/pathogens9030228 |
work_keys_str_mv | AT vandijckchristophe commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance AT laumenjoleinge commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance AT manoharanbasilsheebas commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance AT kenyonchris commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance |