Cargando…

Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance

Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, w...

Descripción completa

Detalles Bibliográficos
Autores principales: Van Dijck, Christophe, Laumen, Jolein G. E., Manoharan-Basil, Sheeba S., Kenyon, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157722/
https://www.ncbi.nlm.nih.gov/pubmed/32204480
http://dx.doi.org/10.3390/pathogens9030228
_version_ 1783522407587250176
author Van Dijck, Christophe
Laumen, Jolein G. E.
Manoharan-Basil, Sheeba S.
Kenyon, Chris
author_facet Van Dijck, Christophe
Laumen, Jolein G. E.
Manoharan-Basil, Sheeba S.
Kenyon, Chris
author_sort Van Dijck, Christophe
collection PubMed
description Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal Neisseria are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral Neisseria communities of intimate partners were more similar than those of unrelated individuals (average Morisita–Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (p = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (p = 0.006)). This similarity presumably results from transmission of oral Neisseria through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in Neisseria. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence.
format Online
Article
Text
id pubmed-7157722
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71577222020-04-21 Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance Van Dijck, Christophe Laumen, Jolein G. E. Manoharan-Basil, Sheeba S. Kenyon, Chris Pathogens Brief Report Antimicrobial resistance in pathogenic Neisseria parallels reduced antimicrobial susceptibility in commensal Neisseria in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal Neisseria are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral Neisseria communities of intimate partners were more similar than those of unrelated individuals (average Morisita–Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (p = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (p = 0.006)). This similarity presumably results from transmission of oral Neisseria through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in Neisseria. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence. MDPI 2020-03-19 /pmc/articles/PMC7157722/ /pubmed/32204480 http://dx.doi.org/10.3390/pathogens9030228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Van Dijck, Christophe
Laumen, Jolein G. E.
Manoharan-Basil, Sheeba S.
Kenyon, Chris
Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title_full Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title_fullStr Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title_full_unstemmed Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title_short Commensal Neisseria Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
title_sort commensal neisseria are shared between sexual partners: implications for gonococcal and meningococcal antimicrobial resistance
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157722/
https://www.ncbi.nlm.nih.gov/pubmed/32204480
http://dx.doi.org/10.3390/pathogens9030228
work_keys_str_mv AT vandijckchristophe commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance
AT laumenjoleinge commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance
AT manoharanbasilsheebas commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance
AT kenyonchris commensalneisseriaaresharedbetweensexualpartnersimplicationsforgonococcalandmeningococcalantimicrobialresistance