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mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice

The design of the mRNA vaccine involves the selection of in vitro transcription (IVT) systems and nonviral delivery vectors. This study aimed to verify the effect of 5’ and 3’ untranslated region (UTR) sequences on the translation efficiency of mRNA. Three modes of IVT-mRNA systems (IVT-mRNA-n1/n2/n...

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Detalles Bibliográficos
Autores principales:	Zhuang, Xinyu, Qi, Yanxin, Wang, Maopeng, Yu, Ning, Nan, Fulong, Zhang, He, Tian, Mingyao, Li, Chang, Lu, Huijun, Jin, Ningyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157730/ https://www.ncbi.nlm.nih.gov/pubmed/32164372 http://dx.doi.org/10.3390/vaccines8010123

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