Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

The need for a malaria vaccine is indisputable. A single vaccine for Plasmodium pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (LS) antigens induced by live attenuated sporozoite...

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Detalles Bibliográficos
Autores principales: Reeder, Sophia M., Reuschel, Emma L., Bah, Mamadou A., Yun, Kun, Tursi, Nicholas J., Kim, Kevin Y., Chu, Jacqueline, Zaidi, Faraz I., Yilmaz, Ilknur, Hart, Robert J., Perrin, Benjamin, Xu, Ziyang, Humeau, Laurent, Weiner, David B., Aly, Ahmed S. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157753/
https://www.ncbi.nlm.nih.gov/pubmed/31936739
http://dx.doi.org/10.3390/vaccines8010021

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