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Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
Two sponges from the Philippines, one a Xestospongia sp. (Haplosclerida, Petrosiidae) and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Ha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Ltd.
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157905/ http://dx.doi.org/10.1016/S0040-4020(99)00465-2 |
| Sumario: | Two sponges from the Philippines, one a Xestospongia sp. (Haplosclerida, Petrosiidae) and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Haplosamates A (1) and B (2) inhibit HIV-1 integrase with IC(50)'s of 50μg/mL and 15μg/mL, respectively. |
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