Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges

Two sponges from the Philippines, one a Xestospongia sp. (Haplosclerida, Petrosiidae) and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Ha...

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Detalles Bibliográficos
Autores principales: Qureshi, Asfia, Faulkner, D.John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157905/
http://dx.doi.org/10.1016/S0040-4020(99)00465-2
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author Qureshi, Asfia
Faulkner, D.John
author_facet Qureshi, Asfia
Faulkner, D.John
author_sort Qureshi, Asfia
collection PubMed
description Two sponges from the Philippines, one a Xestospongia sp. (Haplosclerida, Petrosiidae) and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Haplosamates A (1) and B (2) inhibit HIV-1 integrase with IC(50)'s of 50μg/mL and 15μg/mL, respectively.
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spelling pubmed-71579052020-04-15 Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges Qureshi, Asfia Faulkner, D.John Tetrahedron Article Two sponges from the Philippines, one a Xestospongia sp. (Haplosclerida, Petrosiidae) and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Haplosamates A (1) and B (2) inhibit HIV-1 integrase with IC(50)'s of 50μg/mL and 15μg/mL, respectively. Published by Elsevier Ltd. 1999-07-09 1999-08-03 /pmc/articles/PMC7157905/ http://dx.doi.org/10.1016/S0040-4020(99)00465-2 Text en Copyright © 1999 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Qureshi, Asfia
Faulkner, D.John
Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title_full Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title_fullStr Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title_full_unstemmed Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title_short Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges
title_sort haplosamates a and b: new steroidal sulfamate esters from two haplosclerid sponges
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157905/
http://dx.doi.org/10.1016/S0040-4020(99)00465-2
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