Cargando…

Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()

Coal liquids have been evaluated in a variety of short-term toxicological assays; however, few studies have been conducted to determine the systemic effects after inhalation exposure to these materials. To extend the data base on potential health effects from coal liquefaction materials, we performe...

Descripción completa

Detalles Bibliográficos
Autores principales: Springer, David L., Miller, Rodney A., Weimer, Walter C., Ragan, Harvey A., Buschbom, Ray L., Mahlum, D.Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 1986
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157914/
https://www.ncbi.nlm.nih.gov/pubmed/3753804
http://dx.doi.org/10.1016/0041-008X(86)90444-8
_version_ 1783522435334668288
author Springer, David L.
Miller, Rodney A.
Weimer, Walter C.
Ragan, Harvey A.
Buschbom, Ray L.
Mahlum, D.Dennis
author_facet Springer, David L.
Miller, Rodney A.
Weimer, Walter C.
Ragan, Harvey A.
Buschbom, Ray L.
Mahlum, D.Dennis
author_sort Springer, David L.
collection PubMed
description Coal liquids have been evaluated in a variety of short-term toxicological assays; however, few studies have been conducted to determine the systemic effects after inhalation exposure to these materials. To extend the data base on potential health effects from coal liquefaction materials, we performed a study with solvent refined coal (SRC)-II heavy distillate (HD). Fischer-344 rats were exposed for 6 hr/day, 5 days/week for 5 or 13 weeks to an aerosol of HD (boiling range, 288 to 454°C) at concentrations of 0.69, 0.14, 0.03, or 0.0 mg/liter of air for the high, middle, low, and control groups, respectively. Survival through 13 weeks of exposure was greater than 90% for all groups; body weights for exposed animals were decreased in a dose-dependent manner. significant increases in liver weights and decreases in thymus and ovary weights were observed for treated animals compared with controls. There were also significant treatment-related decreases in erythrocytes, hemoglobin, volume of packed red blood cells, lymphocytes, eosinophils, and total white blood cells. After 5 weeks of exposure serum cholesterol concentrations increased in a dose-dependent manner for both sexes and serum triglyceride amounts decreased for males but not for females. After 13 weeks of exposure, high-dose animals had significant increases in cholesterol (males only), triglycerides, blood urea nitrogen, and serum glutamic pyruvic transaminase (SGPT; males) and significant decreases in albumin, SGPT (females), and lactate dehydrogenase (LDH). Examination of bone-marrow preparations from exposed animals demonstrated consistent decreases in the degree of cellularity, suggesting that this organ is a target for HD. Microscopic evaluation of organ sections indicated exposure-related changes for nasal mucosa, pulmonary macrophages, thymus, liver, kidney, bone marrow, ovaries, and cecum. Results from this study indicated dose-dependent increases in the severity of the lesions observed, with few effects in the low-exposure group that were attributable to the exposure.
format Online
Article
Text
id pubmed-7157914
institution National Center for Biotechnology Information
language English
publishDate 1986
publisher Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-71579142020-04-15 Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid() Springer, David L. Miller, Rodney A. Weimer, Walter C. Ragan, Harvey A. Buschbom, Ray L. Mahlum, D.Dennis Toxicol Appl Pharmacol Article Coal liquids have been evaluated in a variety of short-term toxicological assays; however, few studies have been conducted to determine the systemic effects after inhalation exposure to these materials. To extend the data base on potential health effects from coal liquefaction materials, we performed a study with solvent refined coal (SRC)-II heavy distillate (HD). Fischer-344 rats were exposed for 6 hr/day, 5 days/week for 5 or 13 weeks to an aerosol of HD (boiling range, 288 to 454°C) at concentrations of 0.69, 0.14, 0.03, or 0.0 mg/liter of air for the high, middle, low, and control groups, respectively. Survival through 13 weeks of exposure was greater than 90% for all groups; body weights for exposed animals were decreased in a dose-dependent manner. significant increases in liver weights and decreases in thymus and ovary weights were observed for treated animals compared with controls. There were also significant treatment-related decreases in erythrocytes, hemoglobin, volume of packed red blood cells, lymphocytes, eosinophils, and total white blood cells. After 5 weeks of exposure serum cholesterol concentrations increased in a dose-dependent manner for both sexes and serum triglyceride amounts decreased for males but not for females. After 13 weeks of exposure, high-dose animals had significant increases in cholesterol (males only), triglycerides, blood urea nitrogen, and serum glutamic pyruvic transaminase (SGPT; males) and significant decreases in albumin, SGPT (females), and lactate dehydrogenase (LDH). Examination of bone-marrow preparations from exposed animals demonstrated consistent decreases in the degree of cellularity, suggesting that this organ is a target for HD. Microscopic evaluation of organ sections indicated exposure-related changes for nasal mucosa, pulmonary macrophages, thymus, liver, kidney, bone marrow, ovaries, and cecum. Results from this study indicated dose-dependent increases in the severity of the lesions observed, with few effects in the low-exposure group that were attributable to the exposure. Published by Elsevier Inc. 1986-01 2004-09-24 /pmc/articles/PMC7157914/ /pubmed/3753804 http://dx.doi.org/10.1016/0041-008X(86)90444-8 Text en Copyright © 1986 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Springer, David L.
Miller, Rodney A.
Weimer, Walter C.
Ragan, Harvey A.
Buschbom, Ray L.
Mahlum, D.Dennis
Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title_full Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title_fullStr Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title_full_unstemmed Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title_short Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid()
title_sort effects of inhalation exposure to a high-boiling (288 to 454°c) coal liquid()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157914/
https://www.ncbi.nlm.nih.gov/pubmed/3753804
http://dx.doi.org/10.1016/0041-008X(86)90444-8
work_keys_str_mv AT springerdavidl effectsofinhalationexposuretoahighboiling288to454ccoalliquid
AT millerrodneya effectsofinhalationexposuretoahighboiling288to454ccoalliquid
AT weimerwalterc effectsofinhalationexposuretoahighboiling288to454ccoalliquid
AT raganharveya effectsofinhalationexposuretoahighboiling288to454ccoalliquid
AT buschbomrayl effectsofinhalationexposuretoahighboiling288to454ccoalliquid
AT mahlumddennis effectsofinhalationexposuretoahighboiling288to454ccoalliquid