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Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brai...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158016/ https://www.ncbi.nlm.nih.gov/pubmed/32293472 http://dx.doi.org/10.1186/s12964-020-00549-2 |
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author | Zhou, Yunxiang Shao, Anwen Yao, Yihan Tu, Sheng Deng, Yongchuan Zhang, Jianmin |
author_facet | Zhou, Yunxiang Shao, Anwen Yao, Yihan Tu, Sheng Deng, Yongchuan Zhang, Jianmin |
author_sort | Zhou, Yunxiang |
collection | PubMed |
description | Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brain. As a way of coping with the trauma, astrocytes respond in diverse mechanisms that result in reactive astrogliosis. Astrocytes are involved in the physiopathologic mechanisms of TBI in an extensive and sophisticated manner. Notably, astrocytes have dual roles in TBI, and some astrocyte-derived factors have double and opposite properties. Thus, the suppression or promotion of reactive astrogliosis does not have a substantial curative effect. In contrast, selective stimulation of the beneficial astrocyte-derived molecules and simultaneous attenuation of the deleterious factors based on the spatiotemporal-environment can provide a promising astrocyte-targeting therapeutic strategy. In the current review, we describe for the first time the specific dual roles of astrocytes in neuronal plasticity and reconstruction, including neurogenesis, synaptogenesis, angiogenesis, repair of the blood-brain barrier, and glial scar formation after TBI. We have also classified astrocyte-derived factors depending on their neuroprotective and neurotoxic roles to design more appropriate targeted therapies. |
format | Online Article Text |
id | pubmed-7158016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71580162020-04-20 Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury Zhou, Yunxiang Shao, Anwen Yao, Yihan Tu, Sheng Deng, Yongchuan Zhang, Jianmin Cell Commun Signal Review Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces structural and functional alterations of astrocytes, the most abundant cell type in the brain. As a way of coping with the trauma, astrocytes respond in diverse mechanisms that result in reactive astrogliosis. Astrocytes are involved in the physiopathologic mechanisms of TBI in an extensive and sophisticated manner. Notably, astrocytes have dual roles in TBI, and some astrocyte-derived factors have double and opposite properties. Thus, the suppression or promotion of reactive astrogliosis does not have a substantial curative effect. In contrast, selective stimulation of the beneficial astrocyte-derived molecules and simultaneous attenuation of the deleterious factors based on the spatiotemporal-environment can provide a promising astrocyte-targeting therapeutic strategy. In the current review, we describe for the first time the specific dual roles of astrocytes in neuronal plasticity and reconstruction, including neurogenesis, synaptogenesis, angiogenesis, repair of the blood-brain barrier, and glial scar formation after TBI. We have also classified astrocyte-derived factors depending on their neuroprotective and neurotoxic roles to design more appropriate targeted therapies. BioMed Central 2020-04-15 /pmc/articles/PMC7158016/ /pubmed/32293472 http://dx.doi.org/10.1186/s12964-020-00549-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhou, Yunxiang Shao, Anwen Yao, Yihan Tu, Sheng Deng, Yongchuan Zhang, Jianmin Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title | Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title_full | Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title_fullStr | Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title_full_unstemmed | Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title_short | Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
title_sort | dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158016/ https://www.ncbi.nlm.nih.gov/pubmed/32293472 http://dx.doi.org/10.1186/s12964-020-00549-2 |
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