Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

BACKGROUND: Sustained adrenergic signaling secondary to chronic stress promotes cancer progression; however, the underlying mechanisms for this phenomenon remain unclear. Hepatocellular carcinoma (HCC) frequently develops within fibrotic livers rich in activated hepatic stellate cells (HSCs). Here,...

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Detalles Bibliográficos
Autores principales: Lin, Xia-Hui, Liu, Hua-Hua, Hsu, Shu-Jung, Zhang, Rui, Chen, Jie, Chen, Jun, Gao, Dong-Mei, Cui, Jie-Feng, Ren, Zheng-Gang, Chen, Rong-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158101/
https://www.ncbi.nlm.nih.gov/pubmed/32293507
http://dx.doi.org/10.1186/s13046-020-01568-0

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