Cargando…

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells

BACKGROUND: The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Ji Eun, Eom, Ju-In, Jeung, Hoi-Kyung, Chung, Haerim, Kim, Yu Ri, Kim, Jin Seok, Cheong, June-Won, Min, Yoo Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158163/ https://www.ncbi.nlm.nih.gov/pubmed/32293500 http://dx.doi.org/10.1186/s13046-020-01565-3

Ejemplares similares

ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia
por: Hwang, Doh Yu, et al.
Publicado: (2020)

Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance
por: CHEONG, JUNE-WON, et al.
Publicado: (2016)

DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation
por: Jang, Ji Eun, et al.
Publicado: (2023)

Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells
por: Cho, Hyunsoo, et al.
Publicado: (2021)

Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells
por: Kim, Soo-Jeong, et al.
Publicado: (2012)

Decitabine as a First-Line Treatment for Older Adults Newly Diagnosed with Acute Myeloid Leukemia
por: Park, Hyunsung, et al.
Publicado: (2017)

All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells
por: Kim, Yundeok, et al.
Publicado: (2020)

Pretreatment Epstein-Barr virus DNA in whole blood is a prognostic marker in peripheral T-cell lymphoma
por: Kim, Yu Ri, et al.
Publicado: (2017)

Serum microRNA-21 as a Potential Biomarker for Response to Hypomethylating Agents in Myelodysplastic Syndromes
por: Kim, Yundeok, et al.
Publicado: (2014)

Predictive Factors of Event-Free Survival at 24 Months in Patients with Peripheral T-Cell Lymphoma: A Retrospective Study
por: Kim, Yu Ri, et al.
Publicado: (2022)

Different roles of surveillance positron emission tomography according to the histologic subtype of non-Hodgkin’s lymphoma
por: Kim, Yu Ri, et al.
Publicado: (2021)

Immunosuppressive role of CD11b(+)CD33(+)HLA‐DR(−) myeloid‐derived suppressor cells‐like blast subpopulation in acute myeloid leukemia
por: Hyun, Shin Young, et al.
Publicado: (2020)

Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation
por: Xie, Wensheng, et al.
Publicado: (2015)

Clinical characteristics and treatment outcomes of isolated myeloid sarcoma without bone marrow involvement: a single-institution experience
por: Lee, Jung Yeon, et al.
Publicado: (2017)

HBsAg-Negative, Anti-HBc–Negative Patients Still Have a Risk of Hepatitis B Virus–Related Hepatitis after Autologous Stem Cell Transplantation for Multiple Myeloma or Malignant Lymphoma
por: Park, Hyunsung, et al.
Publicado: (2018)

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling
por: Del Vecchio, Catherine A., et al.
Publicado: (2014)

Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation
por: Fujiki, Tamami, et al.
Publicado: (2019)

PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway
por: Do, Mihyang, et al.
Publicado: (2022)

Glycosylation PERKs
por: Williams, Ruth
Publicado: (2007)

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways
por: Seo, Hye-Young, et al.
Publicado: (2020)

PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis
por: Ji, Guang-rong, et al.
Publicado: (2015)

The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK
por: Wang, Jing, et al.
Publicado: (2018)

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling
por: Zheng, Wei, et al.
Publicado: (2019)

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis
por: Küper, Alina, et al.
Publicado: (2021)

Mr. Charles Perks
Publicado: (1910)

Manganese activates autophagy to alleviate endoplasmic reticulum stress–induced apoptosis via PERK pathway
por: Liu, Chang, et al.
Publicado: (2019)

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
por: Vanhoutte, Davy, et al.
Publicado: (2021)

PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy
por: Zhao, Ning, et al.
Publicado: (2023)

Interaction of Nck1 and PERK phosphorylated at Y(561) negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content
por: Yamani, Lama, et al.
Publicado: (2014)

Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
por: Wei, Ruiran, et al.
Publicado: (2021)

Cytogenetic testing by fluorescence in situ hybridization is improved by plasma cell sorting in multiple myeloma
por: Ha, Jihye, et al.
Publicado: (2022)

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress
por: Lee, Do Yeon, et al.
Publicado: (2010)

Enhancement of Anxiety and Modulation of TH and pERK Expressions in Amygdala by Repeated Injections of Corticosterone
por: Lim, Heena, et al.
Publicado: (2012)

Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
por: Aydin, Yucel, et al.
Publicado: (2017)

The Modified Glasgow Prognostic Scores as a Predictor in Diffuse Large B Cell Lymphoma Treated with R-CHOP Regimen
por: Kim, Yundeok, et al.
Publicado: (2014)

Marliolide Derivative Induces Melanosome Degradation via Nrf2/p62-Mediated Autophagy
por: Yun, Cheong-Yong, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress Mediates Radiation-Induced Autophagy via PERK-eIF2α in Caspase-3/7 Deficient Cells
por: Kim, Kwang Woon, et al.
Publicado: (2010)

P800: CHARACTERIZATION OF REGULATORY T CELLS IN PATIENTS WITH MULTIPLE MYELOMA
por: Kim, Sojeong, et al.
Publicado: (2023)

Development of a Next-generation Sequencing-based Gene Panel Test to Detect Measurable Residual Disease in Acute Myeloid Leukemia
por: Kim, Jin Ju, et al.
Publicado: (2023)

Lymphopenia is an important prognostic factor in peripheral T-cell lymphoma (NOS) treated with anthracycline-containing chemotherapy
por: Kim, Yu Ri, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1hd6bq15urgv797d7l0f1mceei