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Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

Poor aqueous solubility and dissolution of drug candidates drive key decisions on lead series optimization during drug discovery, on formulation optimization, and clinical studies planning during drug development. The interpretation of the in vivo relevance of early pharmaceutical profiling is often...

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Detalles Bibliográficos
Autores principales:	Fink, Christina, Sun, Dajun, Wagner, Knut, Schneider, Melanie, Bauer, Holger, Dolgos, Hugues, Mäder, Karsten, Peters, Sheila‐Annie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158207/ https://www.ncbi.nlm.nih.gov/pubmed/31608434 http://dx.doi.org/10.1002/cpt.1672

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