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Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

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Detalles Bibliográficos
Autores principales:	Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Immunotherapy in Gynecological Cancers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158255/ https://www.ncbi.nlm.nih.gov/pubmed/32313567 http://dx.doi.org/10.1177/1758835920913798

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