Cargando…

Digestive System

The chapter discusses drug-induced changes in the digestive system. The oral mucosa manifests local or systemic disease and derangements produced by therapeutic agents. A significant proportion of therapy-related oral drug reactions appear to be lichenoid reactions, erythema multiforme, and bullous...

Descripción completa

Detalles Bibliográficos
Autor principal: Greaves, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158326/
http://dx.doi.org/10.1016/B978-044452771-4/50009-2
_version_ 1783522517152956416
author Greaves, Peter
author_facet Greaves, Peter
author_sort Greaves, Peter
collection PubMed
description The chapter discusses drug-induced changes in the digestive system. The oral mucosa manifests local or systemic disease and derangements produced by therapeutic agents. A significant proportion of therapy-related oral drug reactions appear to be lichenoid reactions, erythema multiforme, and bullous lesions similar to idiosyncratic or immune-mediated skin reactions. Inflammation of the oral cavity (stomatitis) may involve the buccal mucosa, the gingiva, the tongue, and the peridontal tissues. Stomatitis can be induced by systemic administration of high doses of therapeutic agents. Anticonvulsant drugs may also produce changes in the dentition of humans and experimental animals. Discoloration of the teeth and bone is a well-described adverse effect of tetracycline administration and it has also been reported in patients who were treated with the semisynthetic derivative, minocycline. Drug-induced overgrowth of the gingival tissues is a well-described phenomenon in both humans and laboratory animals, including dogs, cats, and rats. Sessile or pedunculated squamous papillomas and infiltrating squamous carcinomas are occasionally found in the oral cavity of most laboratory animals, including rodents, rabbits, and beagle dogs.
format Online
Article
Text
id pubmed-7158326
institution National Center for Biotechnology Information
language English
publishDate 2007
record_format MEDLINE/PubMed
spelling pubmed-71583262020-04-15 Digestive System Greaves, Peter Histopathology of Preclinical Toxicity Studies Article The chapter discusses drug-induced changes in the digestive system. The oral mucosa manifests local or systemic disease and derangements produced by therapeutic agents. A significant proportion of therapy-related oral drug reactions appear to be lichenoid reactions, erythema multiforme, and bullous lesions similar to idiosyncratic or immune-mediated skin reactions. Inflammation of the oral cavity (stomatitis) may involve the buccal mucosa, the gingiva, the tongue, and the peridontal tissues. Stomatitis can be induced by systemic administration of high doses of therapeutic agents. Anticonvulsant drugs may also produce changes in the dentition of humans and experimental animals. Discoloration of the teeth and bone is a well-described adverse effect of tetracycline administration and it has also been reported in patients who were treated with the semisynthetic derivative, minocycline. Drug-induced overgrowth of the gingival tissues is a well-described phenomenon in both humans and laboratory animals, including dogs, cats, and rats. Sessile or pedunculated squamous papillomas and infiltrating squamous carcinomas are occasionally found in the oral cavity of most laboratory animals, including rodents, rabbits, and beagle dogs. 2007 2007-09-28 /pmc/articles/PMC7158326/ http://dx.doi.org/10.1016/B978-044452771-4/50009-2 Text en Copyright © 2007 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Greaves, Peter
Digestive System
title Digestive System
title_full Digestive System
title_fullStr Digestive System
title_full_unstemmed Digestive System
title_short Digestive System
title_sort digestive system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158326/
http://dx.doi.org/10.1016/B978-044452771-4/50009-2
work_keys_str_mv AT greavespeter digestivesystem