Cargando…

CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms

CpG dinucleotides are suppressed in the genomes of many vertebrate RNA viruses, including HIV-1. The cellular antiviral protein ZAP (zinc finger antiviral protein) binds CpGs and inhibits HIV-1 replication when CpGs are introduced into the viral genome. However, it is not known if ZAP-mediated restr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ficarelli, Mattia, Antzin-Anduetza, Irati, Hugh-White, Rupert, Firth, Andrew E., Sertkaya, Helin, Wilson, Harry, Neil, Stuart J. D., Schulz, Reiner, Swanson, Chad M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158733/ https://www.ncbi.nlm.nih.gov/pubmed/31748389 http://dx.doi.org/10.1128/JVI.01337-19

Ejemplares similares

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides
por: Ficarelli, Mattia, et al.
Publicado: (2019)

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication
por: Antzin-Anduetza, Irati, et al.
Publicado: (2017)

A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods
por: Lista, Maria J., et al.
Publicado: (2023)

Minimal impact of ZAP on lentiviral vector production and transduction efficiency
por: Sertkaya, Helin, et al.
Publicado: (2021)

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene
por: Lin, Yao-Tang, et al.
Publicado: (2020)

Strain-Dependent Restriction of Human Cytomegalovirus by Zinc Finger Antiviral Proteins
por: Lista, Maria Jose, et al.
Publicado: (2023)

Preservation of methylated CpG dinucleotides in human CpG islands
por: Panchin, Alexander Y., et al.
Publicado: (2016)

The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides
por: Odon, Valerie, et al.
Publicado: (2019)

HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency
por: Sertkaya, Helin, et al.
Publicado: (2021)

Selective Depletion of ZAP-Binding CpG Motifs in HCV Evolution
por: Mukherjee, Sanket, et al.
Publicado: (2022)

S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies
por: Kmiec, Dorota, et al.
Publicado: (2021)

CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with the VPS39 Subunit of the Homotypic Fusion and Vacuole Protein Sorting Complex and Promotes Lysosome Clustering
por: Dolata, Katarzyna Magdalena, et al.
Publicado: (2023)

Membrane Interactions and Uncoating of Aichi Virus, a Picornavirus That Lacks a VP4
por: Kelly, James T., et al.
Publicado: (2022)

DEAF1 Binds Unmethylated and Variably Spaced CpG Dinucleotide Motifs
por: Jensik, Philip J., et al.
Publicado: (2014)

Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
por: Sauter, Daniel, et al.
Publicado: (2021)

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence
por: Nguyen, LeAnn P., et al.
Publicado: (2023)

The low abundance of CpG in the SARS-CoV-2 genome is not an evolutionarily signature of ZAP
por: Afrasiabi, Ali, et al.
Publicado: (2022)

Depletion of CpG Dinucleotides in Papillomaviruses and Polyomaviruses: A Role for Divergent Evolutionary Pressures
por: Upadhyay, Mohita, et al.
Publicado: (2015)

Mutation dynamics of CpG dinucleotides during a recent event of vertebrate diversification
por: Pértille, Fábio, et al.
Publicado: (2019)

High Resolution Detection and Analysis of CpG Dinucleotides Methylation Using MBD-Seq Technology
por: Lan, Xun, et al.
Publicado: (2011)

Parvovirus B19 DNA CpG Dinucleotide Methylation and Epigenetic Regulation of Viral Expression
por: Bonvicini, Francesca, et al.
Publicado: (2012)

The CpG dinucleotide content of the HIV-1 envelope gene may predict disease progression
por: Wasson, Mishi Kaushal, et al.
Publicado: (2017)

Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States
por: Buchmuller, Benjamin C., et al.
Publicado: (2020)

Predicting DNA Methylation State of CpG Dinucleotide Using Genome Topological Features and Deep Networks
por: Wang, Yiheng, et al.
Publicado: (2016)

Testosterone Depletion Induces Demethylation of Murine Reelin Promoter CpG Dinucleotides: A Preliminary Study
por: da Silva, Victor Augusto Moraes, et al.
Publicado: (2015)

Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells
por: Trus, Ivan, et al.
Publicado: (2020)

CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation
por: Ayaz, Gamze, et al.
Publicado: (2020)

The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2
por: Di Gioacchino, Andrea, et al.
Publicado: (2021)

Variability in Codon Usage in Coronaviruses Is Mainly Driven by Mutational Bias and Selective Constraints on CpG Dinucleotide
por: Daron, Josquin, et al.
Publicado: (2021)

Adeno-Associated Virus Rep Represses the Human Integration Site Promoter by Two Pathways That Are Similar to Those Required for the Regulation of the Viral p5 Promoter
por: Dutheil, Nathalie, et al.
Publicado: (2014)

Counteracting Effects of Cellular Notch and Epstein-Barr Virus EBNA2: Implications for Stromal Effects on Virus-Host Interactions
por: Rowe, Martin, et al.
Publicado: (2014)

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion
por: Mousnier, Aurelie, et al.
Publicado: (2014)

Genogroup IV and VI Canine Noroviruses Interact with Histo-Blood Group Antigens
por: Caddy, Sarah, et al.
Publicado: (2014)

Host Factors That Interact with the Pestivirus N-Terminal Protease, N(pro), Are Components of the Ribonucleoprotein Complex
por: Jefferson, Matthew, et al.
Publicado: (2014)

Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21
por: Watkinson, R. E., et al.
Publicado: (2013)

The Role of Protein Kinase A Regulation of the E6 PDZ-Binding Domain during the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 18
por: Delury, Craig P., et al.
Publicado: (2013)

Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport
por: Zhou, Zhigang, et al.
Publicado: (2013)

An Unbiased Genetic Screen Reveals the Polygenic Nature of the Influenza Virus Anti-Interferon Response
por: Pérez-Cidoncha, Maite, et al.
Publicado: (2014)

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry
por: Haga, Ismar R., et al.
Publicado: (2014)

A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2
por: Goujon, Caroline, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9cdct3q23371kk7jji5qrbsr2p