Nanoplasmid Vectors Co-expressing Innate Immune Agonists Enhance DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus

DNA vaccines expressing codon-optimized Venezuelan equine encephalitis virus (VEEV) and Ebola virus (EBOV) glycoprotein genes provide protective immunity to mice and nonhuman primates when delivered by intramuscular (IM) electroporation (EP). To achieve equivalent protective efficacy in the absence...

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Detalles Bibliográficos
Autores principales: Suschak, John J., Dupuy, Lesley C., Shoemaker, Charles J., Six, Carolyn, Kwilas, Steven A., Spik, Kristin W., Williams, James A., Schmaljohn, Connie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158766/
https://www.ncbi.nlm.nih.gov/pubmed/32296729
http://dx.doi.org/10.1016/j.omtm.2020.04.009

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