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Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits
Individuals with autistic traits are those who present in the normal population with characteristics of social, communication, personality, and cognitive impairments but do not meet the clinical threshold for autism spectrum disorder (ASD). Most studies have focused on the abnormalities in ASD patie...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158890/ https://www.ncbi.nlm.nih.gov/pubmed/32322224 http://dx.doi.org/10.3389/fpsyg.2020.00523 |
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author | Yaxu, Yu Ren, Zhiting Ward, Jamie Jiang, Qiu |
author_facet | Yaxu, Yu Ren, Zhiting Ward, Jamie Jiang, Qiu |
author_sort | Yaxu, Yu |
collection | PubMed |
description | Individuals with autistic traits are those who present in the normal population with characteristics of social, communication, personality, and cognitive impairments but do not meet the clinical threshold for autism spectrum disorder (ASD). Most studies have focused on the abnormalities in ASD patients rather than on individuals with autistic traits. In this study, we focused on the behaviors of a large sample (N = 401) of Chinese individuals with different levels of autistic traits, measured using the Autism Spectrum Quotient, and applied voxel-based morphometry (VBM) to determine their association to differences in brain structure. The results mainly showed that the correlation between gray matter volume (GMV) and gray matter density of the brain and the Autism Spectrum Quotient was significant in these regions: the right middle frontal gyrus, which are involved in social processing and social reasoning; the left parahippocampal gyrus, which is involved in socioemotional behaviors and unconscious relational memory encoding; and the right superior parietal lobule, which are involved in cognitive control and the ability to show attention to detail. These findings reveal that people with autistic traits in the normal population have atypical development in GMV and gray matter density, which may affect their social functioning and communication ability. |
format | Online Article Text |
id | pubmed-7158890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71588902020-04-22 Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits Yaxu, Yu Ren, Zhiting Ward, Jamie Jiang, Qiu Front Psychol Psychology Individuals with autistic traits are those who present in the normal population with characteristics of social, communication, personality, and cognitive impairments but do not meet the clinical threshold for autism spectrum disorder (ASD). Most studies have focused on the abnormalities in ASD patients rather than on individuals with autistic traits. In this study, we focused on the behaviors of a large sample (N = 401) of Chinese individuals with different levels of autistic traits, measured using the Autism Spectrum Quotient, and applied voxel-based morphometry (VBM) to determine their association to differences in brain structure. The results mainly showed that the correlation between gray matter volume (GMV) and gray matter density of the brain and the Autism Spectrum Quotient was significant in these regions: the right middle frontal gyrus, which are involved in social processing and social reasoning; the left parahippocampal gyrus, which is involved in socioemotional behaviors and unconscious relational memory encoding; and the right superior parietal lobule, which are involved in cognitive control and the ability to show attention to detail. These findings reveal that people with autistic traits in the normal population have atypical development in GMV and gray matter density, which may affect their social functioning and communication ability. Frontiers Media S.A. 2020-04-08 /pmc/articles/PMC7158890/ /pubmed/32322224 http://dx.doi.org/10.3389/fpsyg.2020.00523 Text en Copyright © 2020 Yaxu, Ren, Ward and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Yaxu, Yu Ren, Zhiting Ward, Jamie Jiang, Qiu Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title | Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title_full | Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title_fullStr | Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title_full_unstemmed | Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title_short | Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits |
title_sort | atypical brain structures as a function of gray matter volume (gmv) and gray matter density (gmd) in young adults relating to autism spectrum traits |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158890/ https://www.ncbi.nlm.nih.gov/pubmed/32322224 http://dx.doi.org/10.3389/fpsyg.2020.00523 |
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