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IL1R1 is required for celastrol’s leptin sensitization and anti-obesity effects
Celastrol, a pentacyclic triterpene is the most potent anti-obesity agent that has been reported to date(1). The mechanism of celastrol’s leptin sensitizing and anti-obesity effects has not yet been elucidated. In this study, we identified interleukin 1 receptor 1 (IL1R1) as a mediator of celastrol...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158951/ https://www.ncbi.nlm.nih.gov/pubmed/30833749 http://dx.doi.org/10.1038/s41591-019-0358-x |