Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging

Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe(3)O(4), the fluore...

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Autores principales: Nie, Zhenhui, Luo, Ningbin, Liu, Junjie, Zeng, Xinyi, Zhang, Yu, Su, Danke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158979/
https://www.ncbi.nlm.nih.gov/pubmed/32297036
http://dx.doi.org/10.1186/s11671-020-03309-w
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author Nie, Zhenhui
Luo, Ningbin
Liu, Junjie
Zeng, Xinyi
Zhang, Yu
Su, Danke
author_facet Nie, Zhenhui
Luo, Ningbin
Liu, Junjie
Zeng, Xinyi
Zhang, Yu
Su, Danke
author_sort Nie, Zhenhui
collection PubMed
description Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe(3)O(4), the fluorescent dye Cy5.5, and the CO(2) releasing donor (Na(2)CO(3)). The nanoparticles can continuously generate carbon dioxide (CO(2)) gas in acidic tumour tissue in the body, giving the tumour a strong echo signal under ultrasonic imaging. In addition, the nanoparticles confer excellent effects for MR and fluorescence imaging of the tumour tissue. The results indicate that this pH-responsive NP system provides good effects in MR/US/fluorescent imaging. This study provides a useful reference for multi-mode tumour imaging.
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spelling pubmed-71589792020-04-23 Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging Nie, Zhenhui Luo, Ningbin Liu, Junjie Zeng, Xinyi Zhang, Yu Su, Danke Nanoscale Res Lett Nano Express Gas-filled ultrasound (US) contrast agents easily collapse in the body, and the gas can easily overflow, which limits the effectiveness of US imaging. To address this issue, an injectable gas-generating multi-mode system was developed that carries the MR negative contrast agent Fe(3)O(4), the fluorescent dye Cy5.5, and the CO(2) releasing donor (Na(2)CO(3)). The nanoparticles can continuously generate carbon dioxide (CO(2)) gas in acidic tumour tissue in the body, giving the tumour a strong echo signal under ultrasonic imaging. In addition, the nanoparticles confer excellent effects for MR and fluorescence imaging of the tumour tissue. The results indicate that this pH-responsive NP system provides good effects in MR/US/fluorescent imaging. This study provides a useful reference for multi-mode tumour imaging. Springer US 2020-04-15 /pmc/articles/PMC7158979/ /pubmed/32297036 http://dx.doi.org/10.1186/s11671-020-03309-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Nano Express
Nie, Zhenhui
Luo, Ningbin
Liu, Junjie
Zeng, Xinyi
Zhang, Yu
Su, Danke
Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title_full Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title_fullStr Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title_full_unstemmed Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title_short Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
title_sort multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158979/
https://www.ncbi.nlm.nih.gov/pubmed/32297036
http://dx.doi.org/10.1186/s11671-020-03309-w
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