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Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil

INTRODUCTION: The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate. The frequency of alternative NUDT15 alleles, in particular those that cause a drastic loss...

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Detalles Bibliográficos
Autores principales:	Rodrigues, Juliana Carla Gomes, de Souza, Tatiane Piedade, Pastana, Lucas Favacho, Ribeiro dos Santos, André Maurício, Fernandes, Marianne Rodrigues, Pinto, Pablo, Wanderley, Alayde Vieira, de Souza, Sandro José, Kroll, José Eduardo, Pereira, Adenilson Leão, Magalhães, Leandro, Mercês, Laís Reis das, Vidal, Amanda Ferreira, Vinasco-Sandoval, Tatiana, Cavalcante, Giovanna Chaves, Guerreiro, João Farias, de Assumpção, Paulo Pimentel, Ribeiro-dos-Santos, Ândrea, Santos, Sidney, dos Santos, Ney Pereira Carneiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159207/ https://www.ncbi.nlm.nih.gov/pubmed/32294118 http://dx.doi.org/10.1371/journal.pone.0231651

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